Regulation of 3β-Hydroxysteroid Dehydrogenase Activity in Rat Testis under Hyperprolactinemia and Excessive 17β-Estradiol

NAKAMURA Koji

NAKAMOTO Takahisa

MORIYAMA Hiroyuki

MIZUTAN Masami

SAGAMI Koji

NIHIRA Hiromi

ITO Akihiro

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The effects of hyperprolactinemia on the activity of 3β-hydroxysteroid dehydrogenase (3β-HSD) in rat testis were studied during excessive 17β-estradiol (E2) administration. Without E2 treatment, 3β-HSD activity did not change significantly in moderate hyperprolactinemic rats (756 ± 179 ng/ml). However, this enzyme activity was significantly decreased in marked hyperprolactinemic rats (3612 ± 1090 ng/ml) compared to that in control rats (45.4 ± 6.2 ng/ml). Under the excessive E2 administration, this enzyme activity was insignificantly decreased in slight hyperprolactinemic rats (218 ± 42 ng/ml1 and inhibited in moderate hyperprolactinemic rats (566 ± 77 ng/ml) as refer to control level.
It may be concluded that inhibition of 3β-HSD activity in testis due to the excess administration of estrogen is promoted by the transplantation of MtT/F84 which produces prolactin at the limited level.

3β-hydroxysteroid dehydrogenase

Hyperprolactinemia

17β-estradiol

Rat testis

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3471741