Cellular Immune Competence of Patients with Lung Cancer and Other Lung Diseases. I. Analysis of peripheral blood lymphocyte subsets using monoclonal antibodies
Hiroshima Journal of Medical Sciences Volume 35 Issue 3
Page 227-236
published_at 1986-09
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| File | |
| Title ( eng ) |
Cellular Immune Competence of Patients with Lung Cancer and Other Lung Diseases. I. Analysis of peripheral blood lymphocyte subsets using monoclonal antibodies
|
| Creator |
FUJIWARA Saeko
AKIYAMA Mitoshi
KOBUKE Kyoko
ICHIMARU Shinichiro
TAKAISHI Masatoshi
INAMIZU Tsutomu
KOHNO Nobuoki
TAKAMI Shunsuke
NOUMI Kazumasa
KAWAMOTO Masahide
YAMAKIDO Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 3 |
| Start Page | 227 |
| End Page | 236 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Lymphocyte subsets and lymphocyte responsiveness to mitogens were examined for patients with lung disease and healthy people. The results are as follows:
1) Lymphocytes derived from healthy persons showed an age dependent increase in the percentage of Leu-7+ cells and a decrease in reactivity to phytohemagglutinin (PHA). The percentage of Leu-1+ and Leu-3a+ cells was higher in females than in males under 30 years of age, while the percentage of Leu-7+ cells was higher in males at all ages. 2) Untreated lung cancer patients showed decreases in the percentage of Leu-1+ cells and reactivity to PHA and concanavalin A (Con A), and an increase in the percentage of Leu-11a+ cells. 3) No difference in lymphocyte subsets nor in reactivity to mitogens was observed between patients of different clinical stages. However, when the lymphocyte subsets were compared between patients at each stage and the healthy group, decreased percentages of Leu-1+ and Leu-3a+ in patients with stage IV cancer and Leu-2a+ in those with stage I were observed, while the percentage of Leu-11a+ cells was high in stage I and III patients. 4) No difference in lymphocyte subsets in relation to histological type was observed. 5) Among noncancerous respiratory disease patients, there was a reduced percentage of Leu-1+ cells in sarcoidosis and pulmonary emphysema, and reduced percentages of Leu-1+ and Leu-3a+ cells in pulmonary fibrosis and diffuse panbronchiolitis. |
| Keywords |
Lung cancer
Lymphocyte subsets
Monoclonal antibody
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3804783
|
