Gastrin and Somatostatin in Patients with Hyperchlorhydric Duodenal Ulcer

KISHIMOTO Shinya

TAKABA Norio

OGAWA Mitsuyo

KONEMORI Reiko

KAMBARA Akihiko

OKAMOTO Kazuma

SHIMIZU Satoru

SUMIOKA Masaaki

KOH Hassei

SUMII Kohji

KAJIYAMA Goro

MIYOSHI Akima

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Hormonal and morphological studies were conducted to ascertain the role played by gastrin and somatostatin in the pathophysiology of duodenal ulcer, in particular hyperchlorhydric duodenal ulcer, using 35 patients with duodenal ulcer, of whom 15 were hyperchlorhydric and 20 were normochlorhydric. Twenty normal subjects with normochlorhydria were used as a control. In patients with hyperchlorhydric duodenal ulcer following significant findings were observed:
1. Basal and stimulated hyperchlorhydria,
2. Parietal cell hyperplasia,
3. Basal hypergastrinemia,
4. Increased concentration of gastrin and large number of G cells (G cell hyperplasia) in the antral mucosa.
5. Mucosal concentration of somatostatin and D cells in the antrum was reduced, but the former in patients with hyperchlorhydric duodenal ulcer was not different from that in patients with normoacidic duodenal ulcer.
6. A significant correlation in mucosal concentration was demonstrated between gastrin and somatostatin in control subjects but not in patients with duodenal ulcer.
7. There was a significant correlation in maximal acidity in gastric secretion and mucosal concentration of antral somatostatin in control subjects but not in patients with duodenal ulcer.
8. Concentration of plasma somatostatin in patients with duodenal ulcer was not different from that in control subjects.
These findings indicate that gastrin and somatostatin may participate in the pathophysiology of duodenal ulcer, at least in the subgroup of duodenal ulcer associated with hyperchlorhydria, and the subgroup of duodenal ulcer may be an endocrine disorder.

Duodenal ulcer

Hyperchlorhydria

Gastrin

Somatostatin

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 2870033