The Bioactive Acidic Serine- and Aspartate-Rich Motif Peptide

Minamizaki Tomoko

Yoshiko Yuji

Current Protein & Peptide Science

The organic component of the bone matrix comprises 40% dry weight of bone. The organic component is mostly composed of type I collagen and small amounts of non-collagenous proteins (NCPs) (10-15% of the total bone protein content). The small integrin-binding ligand N-linked glycoprotein (SIBLING) family, a NCP, is considered to play a key role in bone mineralization. SIBLING family of proteins share common structural features and includes the arginine-glycine-aspartic acid (RGD) motif and acidic serine- and aspartic acid-rich motif (ASARM). Clinical manifestations of gene mutations and/or genetically modified mice indicate that SIBLINGs play diverse roles in bone and extraskeletal tissues. ASARM peptides might not be primary responsible for the functional diversity of SIBLINGs, but this motif is suggested to be a key domain of SIBLINGs. However, the exact function of ASARM peptides is poorly understood. In this article, we discuss the considerable progress made in understanding the role of ASARM as a bioactive peptide.

Acidic serine- and aspartic acid-rich motif (ASARM)

bone mineralization

matrix extracellular phosphoglycoprotein (MEPE)

small integrin-binding ligand N-linked glycoprotein (SIBLING)

eng

Bentham Science Publishers

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389203716666150206122839.

This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。

[ISSN] 1389-2037

[ISSN] 1875-5550

[DOI] 10.2174/1389203716666150206122839

[PMID] 25693768

[DOI] https://doi.org/10.2174/1389203716666150206122839