Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL- induced caspase activation

炎症性腸疾患に関連するユビキチンリガーゼRNF183 はリソソームでのDR5の分解およびTRAILによって誘導されるカスパーゼの活性化を促進する

Wu Yan

eng

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Wu, Y., Kimura, Y., Okamoto, T. et al. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep 9, 20301 (2019)

[DOI] https://doi.org/10.1038/s41598-019-56748-6

広島大学