Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells
Scientific Reports Volume 7
Page 41912-
published_at 2017-02-02
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| File | |
| Title ( eng ) |
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells
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| Creator |
Shishido Yurina
Baba Takashi
Sato Tetsuya
Shima Yuichi
Miyabayashi Kanako
Inoue Miki
Akiyama Haruhiko
Kimura Hiroshi
Kanai Yoshiakira
Haraguchi Shogo
Miyazaki Akira
Rozman Damjana
Choi Man-Ho
Ohkawa Yasuyuki
Suyama Mikita
Morohashi Ken-ichirou
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| Source Title |
Scientific Reports
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| Volume | 7 |
| Start Page | 41912 |
| Abstract |
SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry Sertoli cells are not functionally equivalent to XY Sertoli cells, it has remained unclear which specific functions are affected. To elucidate the functional difference, we compared the gene expression of XY and XX/Sry Sertoli cells. Lactate and cholesterol metabolisms, essential for nursing the developing germ cells, were down-regulated in XX/Sry cells, which appears to be caused at least in part by the differential expression of histone modification enzymes SMCX/SMCY (H3K4me3 demethylase) and UTX/UTY (H3K27me3 demethylase) encoded by the sex chromosomes. We suggest that down-regulation of lactate and cholesterol metabolism that may be due to altered epigenetic modification affects the nursing functions of XX/Sry Sertoli cells.
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| Descriptions |
This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 21249018 and 16H05142 (K. Mo.), Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT) KAKENHI Grant Number 22132002 (K. Mo.), the Uehara Memorial Foundation, and Takeda Science Foundation (T.B.).
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Nature Research
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| Date of Issued | 2017-02-02 |
| Rights |
© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 2045-2322
[DOI] 10.1038/srep41912
[PMID] 28150810
[DOI] https://doi.org/10.1038/srep41912
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