Protective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

Watanabe Hiromitsu

Sasatani Megumi

Doi Toshiki

Masaki Takao

Satoh Kenichi

Yoshizumi Masao

American Journal of Hypertension

[BACKGROUND AND HYPOTHESIS] Soybean isoflavones have been shown to reduce the risk of cerebral infarction in humans according to epidemiological studies. However, whether intake of miso can reduce the incidence of stroke in animal models remains unknown. In this study, we investigated the effects of soybean paste (miso) in an animal model of stroke.
[METHODS] Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a miso diet (normal diet 90%, miso 10%; final NaCl content 2.8%), a high salt diet (normal diet and NaCl 2.5%; final NaCl content 2.8%), or a low salt diet (normal diet; final NaCl content 0.3%).
[RESULTS] Kaplan–Meier survival curves revealed a significantly lower survival rate in the high salt group compared to the miso group (P = 0.002) and the low salt group (P ≤ 0.001). Large hemorrhagic macules were found in the cerebrum in the high salt group, whereas none were found in the other 2 groups. There were also fewer histological and immunohistochemical changes in the brain and kidneys in the miso group compared to the high salt group.
[CONCLUSION] Our results suggest that miso may have protective effects against stroke despite its high salt content.

blood pressure

brain protection

hypertension, miso (Japanese soy bean paste)

SHRSP

stroke

eng

Oxford University Press

Copyright © 2017 American Journal of Hypertension, Ltd.

This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'American Journal of Hypertension', copyright c American Journal of Hypertension after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1093/ajh/hpx129.

This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。

[ISSN] 1941-7225

[DOI] 10.1093/ajh/hpx129

[DOI] https://doi.org/10.1093/ajh/hpx129

[PMID] 28985324