Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain
Biological and Pharmaceutical Bulletin 40 巻 7 号
1121-1124 頁
2017-07-01 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain
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| 作成者 |
Ishida Keishi
Saiki Takashi
Umeda Kanae
Miyara Masatsugu
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| 収録物名 |
Biological and Pharmaceutical Bulletin
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| 巻 | 40 |
| 号 | 7 |
| 開始ページ | 1121 |
| 終了ページ | 1124 |
| 抄録 |
Tributyltin (TBT), a common environmental contaminant, is widely used as an antifouling agent in paint. We previously reported that exposure of primary cortical neurons to TBT in vitro decreased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit glutamate receptor 2 (GluR2) expression and subsequently increased neuronal vulnerability to glutamate. Therefore, to identify whether GluR2 expression also decreases after TBT exposure in vivo, we evaluated the changes in GluR2 expression in the mouse brain after prenatal or postnatal exposure to 10 and 25 ppm TBT through pellet diets. Although the mean feed intake and body weight did not decrease in TBT-exposed mice compared with that in control mice, GluR2 expression in the cerebral cortex and hippocampus decreased after TBT exposure during the prenatal period. These results indicate that a decrease in neuronal GluR2 may be involved in TBT-induced neurotoxicity, especially during the fetal period.
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| 著者キーワード |
tributyltin
glutamate receptor 2
developmental neurotoxicity
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| 内容記述 |
This study was supported by JSPS KAKENHI (B) Grant Numbers 23310047 (to Y.K.), 15H02826 (to Y.K.), and a Grant-in-Aid for JSPS Fellows Number 14J06534 (to K.I.).
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
The Pharmaceutical Society of Japan
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| 発行日 | 2017-07-01 |
| 権利情報 |
© 2017 The Pharmaceutical Society of Japan
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0918-6158
[ISSN] 1347-5215
[NCID] AA10885497
[DOI] 10.1248/bpb.b17-00209
[DOI] https://doi.org/10.1248/bpb.b17-00209
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