Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation

Biological and Pharmaceutical Bulletin 35 巻 2 号 269-272 頁 2012-02-01 発行
アクセス数 : 475
ダウンロード数 : 124

今月のアクセス数 : 5
今月のダウンロード数 : 3
ファイル情報(添付)
BiolPhamBull_35_269.pdf 514 KB 種類 : 全文
タイトル ( eng )
Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation
作成者
Saito Ryo
Okuma Yasunobu
Nomura Yasuyuki
収録物名
Biological and Pharmaceutical Bulletin
35
2
開始ページ 269
終了ページ 272
抄録
Endoplasmic reticulum (ER)-associated degradation (ERAD) selectively retro-transports and degrades unfolded proteins accumulated in the ER. We have demonstrated that the ubiquitin ligase HRD1 involved in ERAD was significantly decreased in the cerebral cortex of Alzheimer’s disease patients. Furthermore, the HRD1 level was negatively correlated with amyloid β (Aβ) production levels. Here we found that the HRD1 protein level decrease was due to its insolubilization. Moreover, these protein levels extracted from detergent insoluble fraction were positively correlated with those of SEL1L and Aβs (Aβ40 and Aβ42). Thus, the insolubilization-induced decrease in the HRD1 and SEL1L levels might involve in Aβ generation.
著者キーワード
Alzheimer’s disease
amyloid β
HRD1
endoplasmic reticulum stress
SEL1L
insolubilization
内容記述
This study was supported by Grants-in-Aid for Science Research (KAKENHI) 21790089, 21300142, and 20659013 from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by the Research Foundation for Pharmaceutical Sciences.
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
The Pharmaceutical Society of Japan
発行日 2012-02-01
権利情報
© 2012 The Pharmaceutical Society of Japan
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0918-6158
[ISSN] 1347-5215
[NCID] AA10885497
[DOI] 10.1248/bpb.35.269
[DOI] https://doi.org/10.1248/bpb.35.269