Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation
Biological and Pharmaceutical Bulletin 35 巻 2 号
269-272 頁
2012-02-01 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation
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| 作成者 |
Saito Ryo
Okuma Yasunobu
Nomura Yasuyuki
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| 収録物名 |
Biological and Pharmaceutical Bulletin
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| 巻 | 35 |
| 号 | 2 |
| 開始ページ | 269 |
| 終了ページ | 272 |
| 抄録 |
Endoplasmic reticulum (ER)-associated degradation (ERAD) selectively retro-transports and degrades unfolded proteins accumulated in the ER. We have demonstrated that the ubiquitin ligase HRD1 involved in ERAD was significantly decreased in the cerebral cortex of Alzheimer’s disease patients. Furthermore, the HRD1 level was negatively correlated with amyloid β (Aβ) production levels. Here we found that the HRD1 protein level decrease was due to its insolubilization. Moreover, these protein levels extracted from detergent insoluble fraction were positively correlated with those of SEL1L and Aβs (Aβ40 and Aβ42). Thus, the insolubilization-induced decrease in the HRD1 and SEL1L levels might involve in Aβ generation.
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| 著者キーワード |
Alzheimer’s disease
amyloid β
HRD1
endoplasmic reticulum stress
SEL1L
insolubilization
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| 内容記述 |
This study was supported by Grants-in-Aid for Science Research (KAKENHI) 21790089, 21300142, and 20659013 from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by the Research Foundation for Pharmaceutical Sciences.
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
The Pharmaceutical Society of Japan
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| 発行日 | 2012-02-01 |
| 権利情報 |
© 2012 The Pharmaceutical Society of Japan
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0918-6158
[ISSN] 1347-5215
[NCID] AA10885497
[DOI] 10.1248/bpb.35.269
[DOI] https://doi.org/10.1248/bpb.35.269
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