Activation Signal of Nuclear Factor-κB in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2

Biological and Pharmaceutical Bulletin Volume 26 Issue 7 Page 931-935 published_at 2003-07
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Title ( eng )
Activation Signal of Nuclear Factor-κB in Response to Endoplasmic Reticulum Stress is Transduced via IRE1 and Tumor Necrosis Factor Receptor-Associated Factor 2
Creator
Niinuma Yoshifumi
Nomura Yasuyuki
Source Title
Biological and Pharmaceutical Bulletin
Volume 26
Issue 7
Start Page 931
End Page 935
Abstract
Conditions that perturb the function of the endoplasmic reticulum (ER) lead to an accumulation of proteins and subsequent induction of several responses, such as an increased expression of ER-resident chaperones involved in protein folding and activation of c-jun N-terminal kinase (JNK). These responses are mediated by a transmembrane kinase/ribonuclease, IRE1, which transduces the signal from the ER lumen to the cytosol. Although nuclear transcription factor-κB (NF-κB) is also activated by ER stress, whether this response depends on IRE1 is unknown. In this study, we show that IRE1 is involved in the activation of NF-κB induced by ER stress. NF-κB was activated by ER stress-inducing agents, thapsigargin and tunicamycin. The activation was inhibited by a dominant-negative IRE1. In addition, a dominant-negative TRAF2 also suppressed the activation of NF-κB by ER stress. These results suggest that ER stress-induced NF-κB activation is also mediated by the IRE1-TRAF2 pathway, as well as JNK activation.
Keywords
endoplasmic reticulum (ER) stress
nuclear transcription factor-κB (NF-κB)
IRE1
TRAF2
Descriptions
The present study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
The Pharmaceutical Society of Japan
Date of Issued 2003-07
Rights
© 2003 Pharmaceutical Society of Japan
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0918-6158
[ISSN] 1347-5215
[NCID] AA10885497
[DOI] 10.1248/bpb.26.931
[DOI] https://doi.org/10.1248/bpb.26.931