Improvement of Photodynamic Activity of Lipid-Membrane-Incorporated Fullerene Derivative by Combination with a Photo-Antenna Molecule
Chemistry - A European Journal Volume 24 Issue 29
Page 7335-7339
published_at 2018-05-23
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| File | |
| Title ( eng ) |
Improvement of Photodynamic Activity of Lipid-Membrane-Incorporated Fullerene Derivative by Combination with a Photo-Antenna Molecule
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| Creator |
Antoku Daiki
Satake Shuhei
Mae Tomoya
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| Source Title |
Chemistry - A European Journal
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| Volume | 24 |
| Issue | 29 |
| Start Page | 7335 |
| End Page | 7339 |
| Abstract |
The weak absorbance of pristine C60, C70, and fullerene derivatives at wavelengths over 600 nm hampers the use of these molecules as photosensitizers (PSs) for photodynamic therapy (PDT). The coexistence of light-harvesting antenna molecules with a fullerene derivative in lipid membrane bilayers solved this issue. By controlling the location of the C60 derivative in the lipid membrane, the liposomal dyad system for PDT improved the photodynamic activity via an efficient photoenergy transfer from antenna molecules to the fullerene derivative. The photodynamic activity was found to be much higher than those of dyad systems using pristine C60 and C70.
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| Keywords |
fullerenes
liposomes
energy transfer
photodynamic therapy
photosensitizers
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| Descriptions |
This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
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| NDC |
Chemistry [ 430 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Wiley-VCH
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| Date of Issued | 2018-05-23 |
| Rights |
Copyright (c) 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is the peer reviewed version of the following article: D. Antoku, S. Satake, T. Mae, K. Sugikawa, H. Funabashi, A. Kuroda, A. Ikeda, Improvement of Photodynamic Activity of Lipid-Membrane-Incorporated Fullerene Derivative by Combination with a Photo-Antenna Molecule, Chem.-Eur. J., 24, 7335−7339, 2018, which has been published in final form at https://doi.org/10.1002/chem.201800674. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0947-6539
[ISSN] 1521-3765
[DOI] 10.1002/chem.201800674
[PMID] 29512833
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| Remark | Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months. |
