TNF - α Gene Polymorphism is Likely to be a Risk Factor for NASH in Indonesia
Hiroshima Journal of Medical Sciences 67 巻
101-109 頁
2018-05 発行
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種類 :
全文
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タイトル ( eng ) |
TNF - α Gene Polymorphism is Likely to be a Risk Factor for NASH in Indonesia
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作成者 |
Purnomo Hery Djagat
Ep Mundhofir Farmaditya
Kasno
Sudijanto Edi
Darmono
Daldiyono
Mh Faradz Sultana
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収録物名 |
Hiroshima Journal of Medical Sciences
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巻 | 67 |
開始ページ | 101 |
終了ページ | 109 |
収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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抄録 |
Introduction : Non alcoholic steatohepatitis (NASH) is a subset spectrum of NAFLD that can progress toward cirrhosis. Tumor necrosis factor- α (TNF- α) polymorphism play a significant role in liver inflammation and Insulin resistance its pathophysiological hallmark. The association between TNF- α (-238 and -308) polymorphism) and the severity of NAFLD was evaluated. Method: A total of 155 subjects (80 NAFLD cases and 75 controls) were included. Liver biopsy was performed for evaluated severity of NAFLD based on NAFLD Activity Score-CRN in all cases. Controls subjects defined was not any liver disease by ultrasound. Plasma TNF– α was measured in all subjects. Polymorphism of` TNF- α promoter gene -308 and -238 were identified using PCR-RFLP confirmed with direct sequencing. Results: Liver biopsy established the diagnosis of NASH in 29 cases. There was no association between the incidence of NAFLD with TNF- α polymorphism at the TNF– α -308 or the -238 (p>0.05). The prevalence ratio of TNF– α polymorphism -238 was significantly higher for subject with NASH (p< 0.02). There was no different prevalence ratio for TNF– α polymorphism -308 (p>0,05). We found novel polymorphism of TNF- α -245 T/C in a subject with possible NASH, high plasma TNF- α level (20.27 pg/cc) and very high value of Homeostasis Model of Assessment - Insulin Resistance HOMA-IR (22.73). Conclusion : Polymorphism TNF- α -238 is likely to be a risk factor for NASH in Indonesia. The identification of new possible polymorphism of TNF- α -245 requires further study in more samples.
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著者キーワード |
Polymorphism TNF- α
risk factor
NASH
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NDC分類 |
医学 [ 490 ]
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言語 |
英語
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資源タイプ | 紀要論文 |
出版者 |
Hiroshima University Medical Press
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発行日 | 2018-05 |
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press
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出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
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