TNF - α Gene Polymorphism is Likely to be a Risk Factor for NASH in Indonesia

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タイトル ( eng )
TNF - α Gene Polymorphism is Likely to be a Risk Factor for NASH in Indonesia
作成者
Purnomo Hery Djagat
Ep Mundhofir Farmaditya
Kasno
Sudijanto Edi
Darmono
Daldiyono
Mh Faradz Sultana
収録物名
Hiroshima Journal of Medical Sciences
67
開始ページ 101
終了ページ 109
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Introduction : Non alcoholic steatohepatitis (NASH) is a subset spectrum of NAFLD that can progress toward cirrhosis. Tumor necrosis factor- α (TNF- α) polymorphism play a significant role in liver inflammation and Insulin resistance its pathophysiological hallmark. The association between TNF- α (-238 and -308) polymorphism) and the severity of NAFLD was evaluated. Method: A total of 155 subjects (80 NAFLD cases and 75 controls) were included. Liver biopsy was performed for evaluated severity of NAFLD based on NAFLD Activity Score-CRN in all cases. Controls subjects defined was not any liver disease by ultrasound. Plasma TNF– α was measured in all subjects. Polymorphism of` TNF- α promoter gene -308 and -238 were identified using PCR-RFLP confirmed with direct sequencing. Results: Liver biopsy established the diagnosis of NASH in 29 cases. There was no association between the incidence of NAFLD with TNF- α polymorphism at the TNF– α -308 or the -238 (p>0.05). The prevalence ratio of TNF– α polymorphism -238 was significantly higher for subject with NASH (p< 0.02). There was no different prevalence ratio for TNF– α polymorphism -308 (p>0,05). We found novel polymorphism of TNF- α -245 T/C in a subject with possible NASH, high plasma TNF- α level (20.27 pg/cc) and very high value of Homeostasis Model of Assessment - Insulin Resistance HOMA-IR (22.73). Conclusion : Polymorphism TNF- α -238 is likely to be a risk factor for NASH in Indonesia. The identification of new possible polymorphism of TNF- α -245 requires further study in more samples.
著者キーワード
Polymorphism TNF- α
risk factor
NASH
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 2018-05
権利情報
Copyright (c) 2018 Hiroshima University Medical Press
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312