The role of testicular hyaluronidase in spermatogenesis of mammals

広島大学水畜産学部紀要 1 巻 3 号 321-336 頁 1957-12-25 発行
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タイトル ( eng )
The role of testicular hyaluronidase in spermatogenesis of mammals
タイトル ( jpn )
哺乳動物の精子形成における睾丸性ヒアルロニダーゼの役割
作成者
Yamane Jinshin
Kashiwabara Takao
収録物名
広島大学水畜産学部紀要
Journal of the Faculty of Fisheries and Animal Husbandry
1
3
開始ページ 321
終了ページ 336
抄録
1. Although the chemical action of testicular hyaluronidase peculiar to the mammal has been fairly well defined by the elaboration of numerous biochemists, its physiological significance cannot be seen as fully established.
2. The generalized concept postulated with the idea of "spreading factor", that its dispersal activity on the follicular cell-mass enclosing the ovum is a necesssary antecedent to ensure the fertilization, seems to be unjustifiable because of lack of such a cell-mass at ovulation in a number of mammalian species.
3. The object of this paper is to present the evidence of intracelullar activity of the testicular hyaluronidase indispensable for normal spermatogenesis.
4. A highly purified bovine testicular hyaluronidase was repeatedly injected to the male mouse and rabbit.
5. A remarkable disorganization was observed for a while in spermatogenic epithelia.
6. Lack of meiotic divisions or meiotic irregularities in the spermatocytes and pycnosis or nuclear fragmentation resulting further in debris formation, karyorrhexis and karyolysis of the spermatids were prevailing phenomena.
7. As a consequence, a striking decrease in number of intratubular spermatozoa and a partial infertility occurred.
8. In the sera of rabbits subjected to the injections of hyaluronidase, an antibody which inhibits the dispersal action of homologous enzyme on the follicular cell-mass of rabbit ovum was definitely demonstrated.
9. It follows, therefore, that the disintegration of spermatogenic epithelia particularly meiotic irregularities are results of inhibitory action of antibody which is formed agaist the testicular hyaluronidase administered.
10. The mechanism involved in such a relationship between spermatogenic abnormalities and antigenic effects of hyaluronidase was discussed.
NDC分類
動物学 [ 480 ]
言語
英語
資源タイプ 紀要論文
出版者
広島大学水畜産学部
発行日 1957-12-25
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0440-8756
[NCID] AN00213563