LYSOSOMAL ENZYME RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES IN PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE : THE EFFECT OF HYDROGEN PEROXIDE ON RELEASED ENZYME ACTIVITIES
Hiroshima Journal of Medical Sciences Volume 30 Issue 4
Page 339-344
published_at 1981-12-10
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Title ( eng ) |
LYSOSOMAL ENZYME RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES IN PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE : THE EFFECT OF HYDROGEN PEROXIDE ON RELEASED ENZYME ACTIVITIES
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Title ( jpn ) |
慢性肉芽腫症患者好中球よりのリソゾーム酵素放出について
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Creator |
Tanaka Takeo
Usui Tomofusa
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 30 |
Issue | 4 |
Start Page | 339 |
End Page | 344 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
Lysosomal enzyme release from PMN exposed to STZ was examined using PMN from normal and CGD donors. Normal PMN showed an increase of extracellular lysosomal enzyme activity and a marked reduction of totol (extra-plus intra-cellular) enzyme activity after phagocytosis. On the other hand, in PMN from CGD patients, such a reduction of total enzyme activity was not observed and much more enzyme than normal was released extracellularly. When the supernatant from PMN from CGD patients after phagocytosis of STZ was incubated with an artificial H2O2 generating system, glucose plus glucose oxidase, the enzyme activities were greatly suppressed as the amount of H2O2 rose. A similar result was obtained with the addition of glucose oxidase during phagocytosis in PMN from CGD patients. These findings suggest that the presence of H2O2 might suppress lysosomal enzyme activities and result in inhibition of lysosomal enzyme release.
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Descriptions |
This work was supported in parts by Grants-in-Aid for Scientific Research (Project Nos. 437010 and 544050) from the Ministry of Education, Science, and Culture of Japan.
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University School of Medicine
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Date of Issued | 1981-12-10 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6765683
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