Tumorigenicity Test of N-(5-Nitro-2-Furfurylidene)-1-Aminohydantoin by Dietary Administration in BDF1 Mice

ニトロフラントインの経口投与によるマウスでの発癌性について

Ito Akihiro

Naito Masashi

Naito Yukiko

Watanabe Hiromitsu

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The carcinogenicity of N-(5-Nitro-2-furfurylidene)-1-aminohydan to in (nitrofurantoin, NF-153) was examined in (C57BL/6N×DBA/2N)F1 (BDF1) mice. Three hundred of mice were divided into three groups, each group consisting about 50 male and 50 female mice. Nitrofurantoin was given in powdered diet at dose levels of 0.3, 0.075, or 0 % to the respestive group of mice. The overall incidence of tumors in male and female mice was as follows: 0.3% NF group, 7.7 and 25.9%; 0.075% NF group, 1.9 and 16.7 %; in the control group, 22.6 and 29.6 %, respectively. In the male, the total incidence of tumors in two experimental groups and that of hepatic adenoma in 0.3% NF group was significantly decreased from that of control by p<0.05 and p<0.05, respectively. There was no significant difference in the female. The results in the present study conclude that nitrofurantoin is not carcinogenic in BDF1 mice.

Tumorigenicity

N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

Mouse

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6863018