Effect of M Protein of Streptococcus pyogenes on Macrophage Functions

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Title ( eng )
Effect of M Protein of Streptococcus pyogenes on Macrophage Functions
Title ( jpn )
Streptococcus pyogenes の M protein のマクロファージ機能に及ぼす効果
Creator
Saito Hajime
Tomioka Haruaki
Sato Katsumasa
Watanabe Takashi
Source Title
Hiroshima Journal of Medical Sciences
Volume 32
Issue 2
Start Page 227
End Page 230
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Streptococcal M protein was studied to ascertain its effect on macrophage functions such as oxidative metabolism, phagocytosis, and microbicidal activity. No significant stimulating activity of M protein against macrophage functions such as H2O2 or O2- releasing ability in response to phorbol myristate acetate triggering was noted. M protein did not enhance the macrophage-mediated host risistance to infection with Listeria monocytogenes. However, macrophages elicited with M protein showed a somewhat more enhanced phagocytic activity than did the resident macrophages.
Keywords
M protein
Streptococcus pyogenes
Macrophage Junction
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University School of Medicine
Date of Issued 1983-06
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6618903