The Size of Megakaryocytes in Human Fetal, Infantile and Adult Hematopoiesis

人胎児期，新生児期，幼児期，成人期造血における巨核球面積の変動

Izumi Takaki

Kawakami Masahito

Enzan Hideaki

Ohkita Takeshi

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

It has been reported that the appearance of small megakaryocytes can be detected in　various blood diseases and in fetal hematopoiesis.

In the studies reported herein, we have investigated the age changes in the area of　megakaryocytes during fetal stage to the newborn infant, infant, and adult stage.

The megakaryocyte increased in size from ago of 5 months to 10 months in fetal　stage, and then at the age of one year after birth reached a size almost identical to that　of adults.

In comparing the megakaryocyte area by fetal age, however, the significant difference　was not observed in the hepatic and the bone marrow hematopoiesis at the age of 5　and 7 months.

The results in comparing the area ratio of the nucleus to the cytoplasm of megakaryocytes　indicated that the nucleus of fetel megakaryocytes is generally smaller than that　of adult marrow megakaryocytes.

This finding suggests that the size of the nucleus of megakaryocytes enlarges with　increase in the area of megakaryocytes.

It is also considered that the functional or morphological changes of megakaryocytes　may reflect the function or morphology of the platelet.

Megakaryocyte size

Micromegakaryocyte

Fetal hematopoiesis

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6643104