Nonspecific Mitogen Responses of Peripheral Lymphocytes in Levamisole-Treated Patients with Herpetic Stromal Keratitis

実質型角膜ヘルペス患者の mitogen response について

Sakata Hiroshi

Hiyama Noboru

Kondo Hideaki

Hirakawa Yuji

Yoshida Hideto

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

For the purpose of determining the effect of levamisole on cell-mediated immunity of patients with herpetic stromal keratitis, the response of peripheral lymphocytes to three mitogens (PHA, Con A and PWM) was examined in a total of 19 cases of herpetic stromal keratitis (16 effective cases) including 12 patients undergoing levamisole administration.

As controls, a similar study was made on 35 healthy individuals without any ocular disease and on 19 patients with herpetic stromal keratitis who underwent steroid therapy.

The response of lymphocytes to the three types of mitogens in cases undergoing levamisole therapy did not show any significant difference from that of healthy individuals.

The response of peripheral lymphocytes to PHA and Con A in cases more than 7 months after cessation d levamisole administration and in cases undergoing steroid therapy was significantly elevated when compared with that of healthy cases.

These results suggest that levamisole posseses the action of modulating the function of chiefly T-cells among the lymphocytes, through which it is effective against herpetic stromal keratitis.

Herpetic stromal keratitis

Levamisole

Nonspecific mitogen response

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6534935