Studies on Pathogenesis of Reflux Pancreatitis
Hiroshima Journal of Medical Sciences Volume 33 Issue 4
Page 731-737
published_at 1984-12
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| File | |
| Title ( eng ) |
Studies on Pathogenesis of Reflux Pancreatitis
|
| Title ( jpn ) |
逆流性膵炎の病因に関する研究
|
| Creator |
Kanao Motoo
Nishiki Masayuki
Takasugi Sumiyoshi
Kawanishi Hideki
Ezaki Haruo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 33 |
| Issue | 4 |
| Start Page | 731 |
| End Page | 737 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The behaviors of proteases were examined in the pancreatic juice pooled into a closed duodenal loop and it was confirmed that the activation of proteases occurred quickly after the operation. Three kinds of pancreatic proteases, trypsin, kallikrein and elastase were purified from the pancreatic juice by succesive isoelectric focusing, Soya-bean trypsin inhibitor-Sepharose 4B affinity and Sephadex G-100 column chromatographies. Apparent molecular weights of the purified trypsin, kallikrein and elastase were 26,000, 31,000 and 25,000, respectively. Their isoelectric points were 5.0, 5.0 and 8.0, and their specific activities were 490 TAMe units, 45 TAMe units and 0.47 elastinolytic units/mg protein, respectively. All of these proteases induced a reflux pancreatitis in mongrel dogs and the reflux pancreatitis by the infusion of trypsin was the severest.
|
| Keywords |
Trypsin
Kallikrein
Elastase
Reflux pancreatitis
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1984-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6398812
|
