Distribution of GEP Endocrine Cells in the Gastric Mucosa of Mice with Experimental Gastritis

実験胃炎・胃粘膜の GEP ホルモン細胞動態

Kishimoto Shinya

Konemori Reiko

Mukai Toshikazu

Kambara Akihiko

Okamoto Kazuma

Shimizu Satoru

Iwasaki Yukiyoshi

Daitoku Kunihiko

Kajiyama Goro

Miyoshi Akima

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The aim of this study was to ascertain the morphological changes in the endocrine cell profile in the atrophic mucosa of mice with autoimmune gastritis induced by neonatal thymectomy and administration of carcinogenic chemical, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

Proliferation of argyrophil cells, gastrin (G17, G34) cells in areas of pseudopyloric metaplasia, enteric hormone (GIP, secretin, substance P, enteroglucagon) containing cells and enterochromaffin cells in areas of intestinal metaplasia of the atrophic mucosa was observed in mice with autoimmune gastritis together with proliferation of enterochromaffin-like cells and undifferentiated endocrine cells in their atrophic mucosa. These findings suggest that atrophic mucosae, especially epithelia of pseudopyloric and intestinal metaplasia as well, have the potential of producing endocrine cells which are normally present in the gastric antrum and intestine.

Experimental gastritis GEP hormone cells

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6534922