An Experimental Model for Hyperacute Rejection in Inbred Rat Cardiac Transplantation : Correlation Cardiac Graft Survival Time and Anti T-Cell Warm Cytotoxic Antibody Titer
Hiroshima Journal of Medical Sciences Volume 33 Issue 2
Page 251-257
published_at 1984-06
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| File | |
| Title ( eng ) |
An Experimental Model for Hyperacute Rejection in Inbred Rat Cardiac Transplantation : Correlation Cardiac Graft Survival Time and Anti T-Cell Warm Cytotoxic Antibody Titer
|
| Title ( jpn ) |
ラット心移植における hyperacute rejection モデルの作製
|
| Creator |
Dohi Kiyohiko
Tabe Yasuji
Ezaki Haruo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 33 |
| Issue | 2 |
| Start Page | 251 |
| End Page | 257 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Using genetically homogeneous inbred ACI and Fischer rats, the author has conducted active immunization with the skin and lymphoid cells from ACI rat to Fischer rat and succeeded in making an experimental model that unfailingly causes hyperacute rejection, which has heretofore been considered to be extremely difficult.
Semipermanent survival was gained with syngenetic graft. With allograft, acute rejection of the cardiac graft took place in 8.1±1.4 days. On heart transplantation from ACI to Fischer recipients sensitized by skin graft from ACI and two times active immunization with spleen lymphoid cells from ACI, accelerate rejection occurred in 60.8±32.7 hr. On transplantation of ACI heart in Fischer recipients subjected to skin graft and five times or more hyperimmunization with spleen lymphoid cells, hyperacute rejection of the cardiac graft occurred in all cases in 2.2 ± 3.5 hr. As regards active immunization and anti-T cell warm cytotoxic antibody formation, skin graft followed by five times active immunization gave a titer of 2^8.11 ±1.5 and the antibody formation reached a plateau. Anti-T cell warm cytotoxic antibody and survival time of the cardiac graft showed the following correlation. log10 (y) = －0.054x+2.113 (x<3.622) log10 (y) = －0.4742x+3.4778 (x>3.622) C = 3.622 was recognized. The anti-T cell warm cytotoxic antibodies were found to be decreased with a significant difference (P<0.01) after hyperacute rejection. |
| Keywords |
Hyperacute rejection
Active immunization
Cardiac transplantation
Hyper immunization
Anti T-cell warm cytotoxic antibody
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1984-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6384146
|
