The Serum Pregnancy Associated α2-Glycoprotein Level in Patients with IgA Nephropathy

IgA腎症患者における血清 Pregnancy associated α2-glycoprotein

Toi Shunji

Hamaguchi Naoki

Wada Koji

Toyota Toshihide

Hayashi Kanoko

Arita Michiko

Usui Koji

Tada Misaki

Yorioka Noriaki

Yamakido Michio

Nishimoto Yukio

Hata Jyotaro

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Serum pregnancy associated α2-glycoprotein levels in 51 IgA nephropathy patients (28 males and 23 females) and 46 healthy subjects (31 males and 15 females) were determined by enzyme-immunoassay. The results showed the serum pregnancy associated α2-glycoprotein levels to be significantly increased in the IgA nephropathy patients over the healthy subjects in both sexes (males: p<0.01, females: p<0.001). Further, in the male patients, the level was significantly increased in those with proteinuria, also there was a significant negative correlation between the concentration and PSP 15 minute value and GFR. On the other hand, in the female patient group there was a significant positive correlation between serum total cholesterol level.

On the basis of these findings, we presume that the determination of serum pregnancy associated α2-glycoprotein level may be useful in assuming the prognosis of IgA nephropathy.

Pregnancy associated α2-glycoprotein

IgA nephropathy

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6480376