A Statistical Evaluation on the Age and Sex Distribution of Basal Serum Gastrin and Gastric Acid Secretion in Subjects with or without Peptic Ulcer Disease
Hiroshima Journal of Medical Sciences Volume 33 Issue 2
Page 125-130
published_at 1984-06
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| File | |
| Title ( eng ) |
A Statistical Evaluation on the Age and Sex Distribution of Basal Serum Gastrin and Gastric Acid Secretion in Subjects with or without Peptic Ulcer Disease
|
| Title ( jpn ) |
健常者および消化性潰瘍における血清ガストリン，胃液分泌の年令性分布について
|
| Creator |
Tahir Hamid
Sumii Koji
Haruma Ken
Tari Akira
Uemura Naomi
Shimizu Hideaki
Sumioka Masaaki
Inaba Yoshiro
Kumamoto Takashi
Matsumoto Yuji
Sanuki Eiko
Hirata Ken
Suenaga Kenji
Hidaka Toru
Kajiyama Goro
Miyoshi Akima
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 33 |
| Issue | 2 |
| Start Page | 125 |
| End Page | 130 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The basal serum gastrin concentration and stimulated gastric acid secretion (MAO) were measured in 837 patients at Hiroshima University Hospital.
The basal serum gastrin concentration was significantly higher in males than females in the control group (normal and atrophic gastritis) and it was similar in patients with duodenal (DU) and gastric ulcer (GU), while MAO was significantly higher in males than females in all the groups. The basal serum gastrin concentration increased and MAO decreased with age in the control group. In patients with DU and GU the basal serum gastrin concentration did not change but MAO decreased with age. In patients with DU below 20 years of age, both the basal serum gastrin concentration and MAO were higher than those of age above 20, and were higher than those of the control group less than 20 years old. These findings may support the concept that in the control group increased gastrin release and decreased MAO with age result from achlorhydria or hypochlorhydria or from atrophy of the gastric mucosa; however, in patients with DU, especially in younger patients, gastrin plays a role in hypersecretion of gastric juice. |
| Keywords |
Age
Sex
Gastrin
Gastric acid
Peptic ulcer
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1984-06 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6480375
|
