Interaction between Epidermal Growth Factor and Gastrin on DNA Synthesis of the Gastrointestinal Mucosa in Rats

アクセス数 : 1086
ダウンロード数 : 120

今月のアクセス数 : 5
今月のダウンロード数 : 3
ファイル情報(添付)
HiroshimaJMedSci_37_1.pdf 550 KB 種類 : 全文
タイトル ( eng )
Interaction between Epidermal Growth Factor and Gastrin on DNA Synthesis of the Gastrointestinal Mucosa in Rats
作成者
Sumiyoshi Hiromichi
Oda Noriko
Miyamori Shinji
Kameda Takashi
Takekura Naoki
Takanashi Atsushi
Tahara Eiichi
収録物名
Hiroshima Journal of Medical Sciences
37
1
開始ページ 1
終了ページ 6
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Interaction between epidermal growth factor (EGF) and gastrin on DNA synthesis of the rat gastrointestinal tract was examined. Fasted male rats were divided into four groups and injected with 10 μg/kg human EGF, 300 μg/kg pentagastrin, human EGF plus pentagastrin and saline (control), respectively. The animals were sacrificed 8 or 16 hr thereafter and the incorporation of [3H]thymidine into the gastrointestinal mucosa was measured. Human EGF increased DNA synthesis of the fundus, antrum and cecum, while pentagastrin stimulated that of the fundus, duodenum, ileum and proximal colon. Synchronous administration of these peptides also stimulated DNA synthesis of the fundus, antrum and cecum. However, in the ileum and proximal colon, DNA synthesis stimulated by pentagastrin was suppressed by the administration of both agents synchronously. These data suggest that these growth factors regulate the growth of gastrointestinal tract with complex interactions.
著者キーワード
Human epidermal growth factor
DNA synthesis
Gastrointestinal mucosa
内容記述
This work was supported by Grant-in Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan (59010074, 60010075).
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 1988-03
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3261721