A Case of Cogenital Adrenal Hyperplasia with Concomitant Abnormalities of Steroid 21- and 11β-hydroxylase Activities
Hiroshima Journal of Medical Sciences Volume 39 Issue 4
Page 145-147
published_at 1990-12
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| File | |
| Title ( eng ) |
A Case of Cogenital Adrenal Hyperplasia with Concomitant Abnormalities of Steroid 21- and 11β-hydroxylase Activities
|
| Creator |
Egusa Genshi
Mori Hiroshi
Yamane Kiminori
Okamura Midori
Oda Kiyoshi
Ishida Sakurako
Kado Seijiro
Hara Hitoshi
Yamakido Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 39 |
| Issue | 4 |
| Start Page | 145 |
| End Page | 147 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Abnormalities in the steroid 21-hydroxylase and 11β-hydroxylase activities were suspeted in a 25-year-old female with congenital adrenal hyperplasia (CAH). The patient showed signs of masculinization such as hirsutism, amenorrhea, and enlarged clitoris, but the blood pressure was normal. Adrenocorticotropic was increased to 200 pg/ml. Plasma levels of deoxycorticosterone and 11-deoxyortisol as well as progesterone and 17-hydroxyprogesterone were elevated. Plasma cortisol level was normal at 5.8 μg/dl. CT scan revealed enlargement of the bilataral adrenal glands.
This case suggests that enzyme abnormalities in CAH are more diverse than have been generally considered. |
| Keywords |
Congenital adrenal hyperplasia
21-hydroxylase
11β-hydroxylase
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1990-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 2086566
|
