Mode of Antibacterial Action of Cefprozil, a New Cephalosporin, on Escherichia coli, Serratia marcescens and Morganella morganii
Hiroshima Journal of Medical Sciences Volume 40 Issue 1
Page 35-40
published_at 1991-03
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Title ( eng ) |
Mode of Antibacterial Action of Cefprozil, a New Cephalosporin, on Escherichia coli, Serratia marcescens and Morganella morganii
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Creator |
Nishimoto Kenji
Usui Tsuguru
Miyake Yoichiro
Suginaka Hidekazu
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 40 |
Issue | 1 |
Start Page | 35 |
End Page | 40 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
The mode of antibacterial action of cefprozil (CFPZ, BMY-28100), a newly developed cephalosporin, was investigated using Escherichia coli K12, Serratia marcescens IFO 12648 and Morganella morganii IFO 3848 as test organisms, in comparison with the action of cefaclor (CCL). The minimum inhibitory concentrations (MICs) of CFPZ for these organisms were 1.56, 800 and 25 μg/ml, whereas those of CCL were 1.56, 800 and 100 μg/ml, respectively. The addition of a subinhibitory concentration (1/4 MIC) of ethylenediaminetetraacetic acid (EDTA), which damages the permeability barrier of the outer membrane, markedly reduced the MICs of CFPZ for E. coli and S. marcescens, compared with those of CCL, whereas the MICs of both antibiotics for M. morganii were hardly affected by the presence of EDTA. CFPZ was more stable to β-lactamase activities from these organisms than CCL. The cross-linking reactions of peptidoglycan synthesis catalyzed by the ether-treated cells from these organisms were inhibited by a lower concentration of CFPZ than of CCL.
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Keywords |
Antibacterial action
Cefprozil
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 1991-03 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 1864765
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