A Mapping of Histology and Cell Proliferation in Human Bladder Cancer : An Immunohistochemical Study
Hiroshima Journal of Medical Sciences Volume 44 Issue 4
Page 93-97
published_at 1995-12
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Title ( eng ) |
A Mapping of Histology and Cell Proliferation in Human Bladder Cancer : An Immunohistochemical Study
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Creator |
Igawa Mikio
Urakami Shinji
Shirakawa Hiroki
Shiina Hiroaki
Ishibe Tomoyuki
Usui Tsuguru
Moriyama Hiroyuki
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 44 |
Issue | 4 |
Start Page | 93 |
End Page | 97 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
Transitional cell carcinoma of the urinary bladder is a multifocal disease and the whole bladder mucosa is more or less involved in the neoplastic process. A mapping study of 5 cystectomy specimens was performed, and cell proliferation was evaluated immunohistochemically using anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. A correlation between the pathological findings and the rates of PCNA-positive cells was observed in both the tumor and the surrounding mucosa in 4 of the 5 cases. The rates of PCNA-positive cells increased in areas with normal mucosa adjacent to those with dysplasia or transitional cell carcinoma, and in areas with normal mucosa or dysplasia adjacent to those with carcinoma in situ or transitional cell carcinoma in 2 cases. These features may indicate that a field change observed in the mapping study of a bladder with cancer is a manifestation of a stepwise progression of the mucosal disease.
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Keywords |
Mapping
Bladder cancer
Cell proliferation
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 1995-12 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
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