Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy

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Title ( eng )
Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy
Creator
Hirabayashi Akira
Yorioka Noriaki
Oda Hiroaki
Sekiguchi Yoshitaka
Kuramoto Atsushi
Okushin Sayuri
Yamakido Michio
Source Title
Hiroshima Journal of Medical Sciences
Volume 45
Issue 4
Start Page 113
End Page 117
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
To investigate the involvement of bacterial antigens in Immunoglobulin A (IgA) nephropathy, we measured IgA, IgG and IgM antibodies to gram-negative Escherichia coli (E.coli) and Haemophilus influenzae (H.influenzae) by ELISA in 24 patients (11 males and 13 females) with IgA nephropathy and 22 normal controls (11 males and 11 females). The titers of IgA and IgM antibodies for E.coli and H.influenzae were significantly higher in the IgA nephropathy group than in the controls. In addition, IgA and IgM antibody titers for E.coli and H.influenzae showed a significant positive correlation with serum IgA and IgM levels. These findings suggest that subclinical infection by these bacteria stimulates IgA production and that this may be a factor in the development and progression of IgA nephropathy.
Keywords
Escherichia coli
Haemophilus influenzae
Immunoglobulin A nephropathy
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1996-12
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312