Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy
Hiroshima Journal of Medical Sciences Volume 45 Issue 4
Page 113-117
published_at 1996-12
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| File | |
| Title ( eng ) |
Involvement of Bacterial Antigens in Immunoglobulin A Nephropathy
|
| Creator |
Hirabayashi Akira
Yorioka Noriaki
Oda Hiroaki
Sekiguchi Yoshitaka
Kuramoto Atsushi
Okushin Sayuri
Yamakido Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 45 |
| Issue | 4 |
| Start Page | 113 |
| End Page | 117 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
To investigate the involvement of bacterial antigens in Immunoglobulin A (IgA) nephropathy, we measured IgA, IgG and IgM antibodies to gram-negative Escherichia coli (E.coli) and Haemophilus influenzae (H.influenzae) by ELISA in 24 patients (11 males and 13 females) with IgA nephropathy and 22 normal controls (11 males and 11 females). The titers of IgA and IgM antibodies for E.coli and H.influenzae were significantly higher in the IgA nephropathy group than in the controls. In addition, IgA and IgM antibody titers for E.coli and H.influenzae showed a significant positive correlation with serum IgA and IgM levels. These findings suggest that subclinical infection by these bacteria stimulates IgA production and that this may be a factor in the development and progression of IgA nephropathy.
|
| Keywords |
Escherichia coli
Haemophilus influenzae
Immunoglobulin A nephropathy
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1996-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
