Effect of Donor Fasting on Survival of Pancreas and Heart Grafts after Warm Ischemia

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Title ( eng )
Effect of Donor Fasting on Survival of Pancreas and Heart Grafts after Warm Ischemia
Creator
Nishihara Masahiro
Sumimoto Ryo
Asahara Toshimasa
Fukuda Yasuhiko
Southard J.H.
Dohi Kiyohiko
Source Title
Hiroshima Journal of Medical Sciences
Volume 45
Issue 3
Start Page 93
End Page 97
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Livers from fasted animals are believed to be more vulnerable to ischemic injury than those from fed donors. However, we have recently shown the opposite: livers from fasted rats were more tolerant to ischemic injury. Indeed, the survival rate of 60 min warm ischemic damaged livers increased from 0 to 90% if donor rats were fasted for three days. In this study, we examined how donor fasting affects the outcome of pancreas and heart preservation. BN rats were used as both donors and recipients, and recipients of pancreatic grafts were rendered diabetic prior to transplantation. Pancreatic or heart grafts were subjected to 90 min or 25 min of warm ischemia and were transplanted into the right side of the necks of recipient rats. The viability rate of hearts transplanted from fed donors into fed recipients was only about 11 % (1/9) after transplantation. However, the viability rate with fasted donors was 75% (6/8). The rate of successful pancreatic grafting from fed donors into fed recipients was 28.6% (2/7), and that from fasted donors to fed recipients was 41.7% (5/12). These results confirm that the nutritional status of the donor is an important factor in the outcome of not only liver, but also pancreas and heart preservation during transplantation, although the effect of fasting on pancreatic graft is marginal.
Keywords
Heart transplantation
Pancreas transplantation
Warm ischemia
Fasting
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1996-09
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312