Dietary NaCl Loading Increases Platelet Ca2+ Discharge Capacity in Salt Resistant Essential Hypertension
Hiroshima Journal of Medical Sciences Volume 45 Issue 1
Page 23-30
published_at 1996-03
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Title ( eng ) |
Dietary NaCl Loading Increases Platelet Ca2+ Discharge Capacity in Salt Resistant Essential Hypertension
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Creator |
Watanabe Mitsuaki
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 45 |
Issue | 1 |
Start Page | 23 |
End Page | 30 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
To clarify the relationship between cellular Ca2+ handling and salt sensitivity, we evaluated cytosolic free Ca2+ ([Ca2+]i) in fura-2 loaded platelets isolated from 20 inpatients with essential hypertension. They were placed on a low sodium diet (50 mmol/day) for one week, followed by one week on a high sodium diet (340 mmol/day). They were classified into salt-sensitive (SS, n=8) or salt-resistant (SR, n=12) based on changes in the mean blood pressure. During the low salt diet, basal [Ca2+]i, thrombin-evoked maximal Ca2+ responses, irrespective of the presence of 1 mM extracellular Ca2+, and ionomycin-sensitive intracellular Ca2+ discharge capacity were similar in salt-sensitive and salt-resistant patients. Platelet basal [Ca2+]i were increased in both groups by salt loading (SS, from 22.0±1.3 to 27.2±1.9 nM, p<0.01; SR, from 20.1±0.8 to 24.4±1.3 nM, p<0.05). The thrombin-evoked maximal Ca2+ responses both in the presence and absence of extracellular Ca2+ were unchanged by high salt intake. The rate constant of decline in Ca2+ after the peak response to thrombin was larger in SR than that in SS during the high salt diet period (SS, 0.004 ± 0.001 sec-1; SR, 0.043 ± 0.014 sec-1, p<0.05). The intracellular Ca2+ discharge capacity was increased by excessive salt intake in the salt-resistant patients but was unchanged in the salt-sensitive patients (SS, from 658. l ± 52.8 to 639.6 ± 91.9 nM; SR, from 690.8 ± 65.1 to 803.3 ± 65.1 nM, p<0.05). An increased intracellular Ca2+ discharge capacity may play, at least in part, a significant role in preventing the elevation of blood pressure after salt loading in salt-resistant patients with essential hypertension.
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Keywords |
Salt sensitivity
Calcium
Platelet
Essential hypertension
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Descriptions |
This paper was presented in part at 49th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, New Orleans, Louisiana, September 19-22, 1995
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 1996-03 |
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
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