Examination of Serum Amyloid A Protein in Kidney Transplant Patients : Comparison of Serum Amyloid A and C-Reactive Protein for Mani to ring the Occurrence of Renal-allograft-related Complications

アクセス数 : 981
ダウンロード数 : 145

今月のアクセス数 : 1
今月のダウンロード数 : 0
File
HiroshimaJMedSci_47_63.pdf 510 KB 種類 : fulltext
Title ( eng )
Examination of Serum Amyloid A Protein in Kidney Transplant Patients : Comparison of Serum Amyloid A and C-Reactive Protein for Mani to ring the Occurrence of Renal-allograft-related Complications
Creator
Fukuda Yasuhiko
Kanbe Masayuki
Sumimoto Ryo
Yoneya Taiko
Takeshita Takenori
Hoshino Shuji
Shintaku Sadanori
Dohi Kiyohiko
Source Title
Hiroshima Journal of Medical Sciences
Volume 47
Issue 2
Start Page 63
End Page 67
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Serum amyloid A (SAA) is an inflammation -reactive protein, like C-reactive protein (CRP). In this study, we examined SAA levels in the sera of kidney transplant patients with acute rejection (N=12), chronic rejection (N=60) and cytomegalovirus (CMV) infection complications and compared them with serum CRP levels in terms of sensitivity and reactivity. The SAA and CRP showed almost similar kinetics in 10 patients within 2 months of kidney transplantation. However, in 2 patients SAA responded more sensitively to CMV infection and acute rejection. SAA increased significantly 10-fold relative to its baseline levels. The SAA levels also increased along with those of serum creatinine levels. Our experiments clearly showed that SAA and CRP responded sensitively to several stimuli with elevated serum levels including surgical trauma, acute allograft rejection and infection. However, the reactivity and sensitivity of SAA was clearly higher than those of CRP in patients with viral infections, on steroid therapy and undergoing chronic allograft rejection, suggesting that monitoring SAA levels provides more useful information than monitoring CRP.
Keywords
Serum amyloid A protein
C-reactive protein
Kidney transplantation
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1998-06
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312