Pranlukast, a Cysteinyl Leukotriene Antagonist, Reduces Serum Eosinophil Cationic Protein Levels in Patients with Asthma
Hiroshima Journal of Medical Sciences Volume 48 Issue 4
Page 105-110
published_at 1999-12
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| File | |
| Title ( eng ) |
Pranlukast, a Cysteinyl Leukotriene Antagonist, Reduces Serum Eosinophil Cationic Protein Levels in Patients with Asthma
|
| Creator |
Ishioka Shinichi
Hozawa Soichiro
Hiyama Keiko
Maeda Akihiro
Yamakido Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 48 |
| Issue | 4 |
| Start Page | 105 |
| End Page | 110 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Cysteinyl leukotrienes (cysLTs) are considered to be important mediators involved in bronchial asthma and the ensuing eosinophilic inflammation. We evaluated the effects of pranlukast, a potent and selective cysLT receptor antagonist, on the clinical course and serum eosinophil cationic protein (ECP) levels of 10 asthmatic patients. A four-week administration of pranlukast increased the morning peak expiratory flow (PEF) (p=0.007) and decreased as-needed /3z-agonist use (p=0.021). Changes in the morning PEF inversely correlated with those in the serum ECP levels (r=－0.80, p=0.0057). These results suggest that cysLTs are important mediators involved in eosinophilic inflammation, a major pathophysiologic feature of bronchial asthma in humans.
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| Keywords |
Bronchial asthma
Cysteinyl leukotriene receptor antagonist
Pranlukast
Serum eosinophil cationic protein
|
| Descriptions |
Part of this study was supported by a research grant from the Japanese Ministry of Health and Welfare.
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1999-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
