V1 Receptor Activation Induced by Hemorrhage and Sympathoinhibition in the Mesentery and Hindquarters of Spontaneously Hypertensive Rats
Hiroshima Journal of Medical Sciences Volume 54 Issue 4
Page 93-99
published_at 2005-12
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Title ( eng ) |
V1 Receptor Activation Induced by Hemorrhage and Sympathoinhibition in the Mesentery and Hindquarters of Spontaneously Hypertensive Rats
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Creator |
Xing Chi Hong
Teranishi Yasuhiro
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 54 |
Issue | 4 |
Start Page | 93 |
End Page | 99 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
The aim of this study was to determine the effects of vasopressin V 1 receptor antagonism on regional hemodynamics in spontaneously hypertensive rats (SHR/Izm). Changes in blood flow in the superior mesenteric artery or terminal aorta were measured in rats with a chronically implanted electromagnetic flowmeter. The combination of a non-hypotensive hemorrhage (0.3 ml/100 g weight) and ganglionic blockade with hexamethonium bromide (C6; 25 mg/kg weight) had no effect on mesenteric resistance. On the other hand, subsequent intravenous administration of a peptide vasopressin V1 receptor antagonist (V1A; 10 μg/kg:[d(CH2)5 1-O Methyl-Tyr2-Arg8]-vasopressin) significantly reduced mesenteric resistance in SHR/Izm but had no effect on hindquarter resistance. Furthermore, the infusion of C6 (after pretreatment with hemorrhage plus V 1A) induced a marked reduction of blood pressure and a significant decrease in superior mesenteric resistance only in SHR/Izm. Thus, we showed an altered reactivity to V1A in the superior mesenteric and/or hindquarter vascular regions of SHR/Izm, suggesting that maintenance of elevated resistance in the mesenteric vascular bed mainly relates to a potential vasopressin- mediated vasoconstriction and that a new sympathetic vasoconstrictor tone is generated within the superior mesenteric vascular bed to compensate for hypotensive intervention (minor hemorrhage plus V 1A) in conscious SHR/Izm.
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Keywords |
Regional blood flow
Hemorrhage
Ganglionic blockade
V1 receptor antagonist
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 2005-12 |
Rights |
Hiroshima University Medical Press
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Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
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