NATURAL KILLER (NK) ACTIVITY IN CHILDREN WITH ACUTE L YMPHOBLASTIC LEUKEMIA
Hiroshima Journal of Medical Sciences Volume 30 Issue 2
Page 127-133
published_at 1981-06-10
アクセス数 : 764 件
ダウンロード数 : 95 件
今月のアクセス数 : 3 件
今月のダウンロード数 : 0 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00037368
| File | |
| Title ( eng ) |
NATURAL KILLER (NK) ACTIVITY IN CHILDREN WITH ACUTE L YMPHOBLASTIC LEUKEMIA
|
| Title ( jpn ) |
急性リンパ性白血病患児のナチュラル・キラー(NK)活性について
|
| Creator |
Tanaka Yoshito
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 30 |
| Issue | 2 |
| Start Page | 127 |
| End Page | 133 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The natural killer (NK) activity against K 562 target cells was explored in 20 children with acute lymphoblastic leukemia (ALL).
Three of 5 patients examined at the time of diagnosis had normal NK activity. Two patients, who had more than 80% circulating blasts had significantly low NK activity. The level of NK activity of these 5 patients was inversely proportional to the percentage of blast cells contaminating the effector cell populations. After initiating induction chemotherapy, the NK activity decreased in spite of disappearance of circulating blasts. After complete remission, their NK activity returned to normal levels, and was rather higher than that of onset of the disease. NK activity of 15 children with ALL remaining in continuous complete remission was as high as that of healthy children and healthy adults in spite of intensive maintenance chemotherapy for 1/2 to 4 years. This was thought to be due to intermittent dose-schedule of the maintenance chemotherapy. |
| Descriptions |
This work was supported by a Research Grant (No. 544050) from the Ministry of Education, Science and Culture of Japan.
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1981-06-10 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
