New Dopamine Agonist Pramipexole Improves Parkinsonism and Depression in Parkinson's Disease

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Title ( eng )
New Dopamine Agonist Pramipexole Improves Parkinsonism and Depression in Parkinson's Disease
Creator
Harada Toshihide
Ishizaki Fumiko
Horie Nobuko
Nitta Yumiko
Yamada Tohru
Sasaki Tomohiro
Nagakane Tomoomi
Yasumatsu Yoshiteru
Nitta Kohsaku
Katsuoka Hiroyuki
Source Title
Hiroshima Journal of Medical Sciences
Volume 60
Issue 4
Start Page 79
End Page 82
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Previous studies have shown that pramipexole might have the potential to improve depressive symptoms in patients with Parkinson's disease. To provide more evidence, in five Japanese patients at Hoehn & Yahr stage 1-3 we evaluated the Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Rating Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS) at our hospital. After the pramipexole treatment, each total score of UPDRS, HAMD and MADRS significantly decreased compared with that before the treatment. Our data indicate that pramipexole improves depressive symptoms in patients with Parkinson's disease.
Keywords
Parkinson's disease
Depression
Pramipexole
UPDRS
MADRS
HAMD
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2011-12
Rights
(c) Hiroshima University Medical Press.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312