Efficacy and Safety of Topical Travoprost with Sofzia(R) Preservative for Japanese Glaucoma Patients
Hiroshima Journal of Medical Sciences Volume 59 Issue 4
Page 71-75
published_at 2010-12
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Title ( eng ) |
Efficacy and Safety of Topical Travoprost with Sofzia(R) Preservative for Japanese Glaucoma Patients
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Creator |
Kanamoto Takashi
Suehiro Tatsunori
Nakano Tohru
Nakano Yutaka
Hirota Atsushi
Miyata Akira
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Source Title |
Hiroshima Journal of Medical Sciences
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Volume | 59 |
Issue | 4 |
Start Page | 71 |
End Page | 75 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
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Abstract |
The purpose of this study is to evaluate the intraocular pressure (IOP) -lowering effect and safety of topical travoprost with sofziaR and without benzalkonium chloride on Japanese patients with glaucoma. Topical travoprost (0.04%) was used on 39 glaucoma patients with no prior use of topical prostaglandin F2a analogues (Beginning group). The IOP, number of conjunctiva! follicules, degrees of conjunctiva! hyperemia, and degrees of superficial punctate keratitis (SPK, AD-classification) were determined at the beginning of the treatment and after 1 month and 3 months. 37 other patients who were using 0.005% topical latanoprost were switched to 0.04% topical travoprost and analyzed in the same way (Switched group). For the Beginning group, the IOP was significantly decreased after 3 months (p <0.0001). The conjunctiva! follicule score was decreased significantly (p =0.033). Both the SPK area score and density score for the cases with SPK at the baseline decreased significantly (p =0.034 and p =0.024). In the switched group, the IOP was not changed significantly at 3 months after the switch (p =0.118). Both the conjunctiva! follicule and hyperemia score were significantly decreased at 3 month (p =0.0074 and p =0.0047). The SPK area score for the cases with SPK at the time of switch decreased significantly (p =0.013). Travoprost with sofziaR preservative had an equal effect in reducing the IOP as latanoprost. It had low toxicity on the ocular surface of Japanese glaucoma patients.
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Keywords |
Travoprost
Glaucoma
Intraocular pressure
Safety
SofziaR
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
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Date of Issued | 2010-12 |
Rights |
(c) Hiroshima University Medical Press.
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Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
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