Association of Typical versus Atypical Antipsychotics with Symptoms and Quality of Life in Schizophrenia

PLoS ONE Volume 7 Issue 5 Page e37087- published_at 2012
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Title ( eng )
Association of Typical versus Atypical Antipsychotics with Symptoms and Quality of Life in Schizophrenia
Creator
Koichiro Fujimaki
Terumichi Takahashi
Shigeru Morinobu
Source Title
PLoS ONE
Volume 7
Issue 5
Start Page e37087
Abstract
Background: Several reports on patients with chronic schizophrenia suggest that atypical versus typical antipsychotics are expected to lead to better quality of life (QOL) and cognitive function. Our aim was to examine the association of chronic treatment with typical or atypical antipsychotics with cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms in long-hospitalized patients with schizophrenia.

Methodology and Principal Findings: The Hasegawa Dementia Scale-Revised (HDS-R), Brief Psychiatric Rating Scale (BPRS), the Schizophrenia Quality of Life Scale, translated into Japanese (JSQLS), and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) were used to evaluate cognitive function, psychiatric symptoms, QOL, and drug-induced extrapyramidal symptoms. We examined the correlation between the dose of antipsychotics and each measure derived from these psychometric tests. The student t-test was used to compare scores obtained from psychometric tests between patients receiving typical and atypical antipsychotics. Results showed significant correlations between chlorpromazine (CPZ)-equivalent doses of typical antipsychotics and atypical antipsychotics, and the total BPRS score and BPRS subscale scores for positive symptoms. CPZ-equivalent doses of typical antipsychotics were correlated with the JSQLS subscale score for dysfunction of psycho-social activity and DIEPSS score. Furthermore, the total BPRS scores, BPRS subscale score for positive symptoms, the JSQLS subscale score for dysfunction of psycho-social activity, and the DIEPSS score were significantly higher in patients receiving typical antipsychotics than atypical antipsychotics.

Conclusion and Significance: These findings suggest that long-term administration of typical antipsychotics has an unfavorable association with feelings of difficulties mixing in social situations in patients with chronic schizophrenia.
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
Public Library of Science
Date of Issued 2012
Rights
(c) 2012 Fujimaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 1932-6203
[DOI] 10.1371/journal.pone.0037087
[DOI] http://dx.doi.org/10.1371/journal.pone.0037087