Effect of N-feruloyl tyramine (an analogue of tyramine) on inwardly rectifying potassium channel in frog ventricular myocytes
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この文献の参照には次のURLをご利用ください : https://doi.org/10.11501/3119814
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Title ( eng ) |
Effect of N-feruloyl tyramine (an analogue of tyramine) on inwardly rectifying potassium channel in frog ventricular myocytes
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Title ( jpn ) |
チラミン類縁体N-フェルロイルチラミンによるカエル心室筋内向き整流性カリウムチャンネルに対する影響
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Creator |
Munemori Makoto
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Abstract |
Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 ,#uM, while tyramine (100 #M) was ineffective in producing an inhibitory effect on iK1. NFT reduced the mean open time of iK1 to 1.3 ms from 3.1 ms in control without affecting the amplitude of single-channel conductance. It is indicated that boi containing NFT produces a prolongation of the plateau phase caused by the suppression of inwardly rectifying K channel. Thus, this prolongation may induce an increase in the inflow of Ca ions, which in turn leads to a positive inotropic effect.
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Keywords |
NFT
iK1
Suppression
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | doctoral thesis |
Rights |
Copyright(c) by Author
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Publish Type | Not Applicable (or Unknown) |
Access Rights | open access |
Source Identifier |
Hiroshima J. Med. Sci. Vol.45, No.1, 31-35, March, 1996. HIJM45-5
references
[PMID] 8984103
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Dissertation Number | 甲第1484号 |
Degree Name | |
Date of Granted | 1996-03-26 |
Degree Grantors |
広島大学
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