Protective effects of a water-soluble extract from cultured medium of Gall o de rIll a luciduln (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3Fl mice : Increased small intestinal crypt survival and prolongation of average time to anilnaI death

Kubo Nanami

Myojin Yuki

Shimamoto Fumio

Kashimoto Naoki

Kyo Eikai

Kamiya Kenji

Watanabe Hiromitsu

International Journal of Molecular Medicine

Radioprotective effects of a water-soluble extracts from cultured medium of Ganoderma lucidum (Rei-shi) mycelia (designed as MAK) and Agaricus blazei (Agaricus) against the shortening of survival time or the injury of crypt by X-irradiation were investigated in male B6C3F1 mice. MAK and Agaricus at three different doses were mixed into basal diet into biscuits at 5, 2.5 and 1.25% and administered from 1 week before irradiation. MAK (5% group) significantly prolonged animal survival as compared with basal diet group (control group) after 7 Gy of X-ray irradiation at a dose rate of 2 Gy min-1. At doses of 8, 10 and 12 Gy X-irradiation at a dose rate of 4 Gy min-1 MAK (5% group) significantly increased crypt survival as compared to other groups. These results suggest that MAK can act as a radioprotective agent.

radiation protection

crypt survival

survival

Ganoderma luciduml (Rei-shi) mycelia

Agaricus blazei

B6C3F1 mouse

Medical sciences [ 490 ]

eng

Spandidos Publications Ltd.

Copyright (c) 2005 Spandidos Publications Ltd.

[ISSN] 1107-3756

[NCID] AA11445762