Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer
Bioorganic & Medicinal Chemistry Volume 17 Issue 11
Page 25-28
published_at 2009-01-01
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| File | |
| Title ( eng ) |
Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer
|
| Creator |
Fujii Misato
Akita Kazuhiro
Ogawa Kaori
Kuroyanagi Masanori
Hongo Daiki
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| Source Title |
Bioorganic & Medicinal Chemistry
|
| Volume | 17 |
| Issue | 11 |
| Start Page | 25 |
| End Page | 28 |
| Abstract |
On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3′,4′-pentamethoxyflavone had the greatest anti-corpulence effects and 3,5,6,7,8,3′,5′-heptamethoxyflavone had the greatest anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses.
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| Keywords |
Cirtus fruits
Anti-corpulence
Anticancer
Polymethoxyflavones
Coumarin derivatives
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| NDC |
Chemistry [ 430 ]
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| Language |
eng
|
| Resource Type | journal article |
| Publisher |
Elsevier Science BV
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| Date of Issued | 2009-01-01 |
| Rights |
Copyright (c) 2008 Elsevier Ltd
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0968-0896
[DOI] 10.1016/j.bmc.2008.11.039
[NCID] AA10938083
[DOI] http://dx.doi.org/10.1016/j.bmc.2008.11.039
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