Tumor Induction by Azoxymethane (AOM) and 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 Rat Gastric Mucosa Featuring Intestinal Metaplasia Caused by X-irradiation

Kashiwabara Shoji

Kashimoto Naoki

Uesaka Toshihiro

Wakabayashi Keiji

Kamiya Kenji

Watanabe Hiromitsu

Journal of Experimental & Clinical Cancer Research

Male F344 5-week-old rats were X-irradiated, and 16 weeks after the first dose. azoxymethane (AOM) was injected or 2-amino-l-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) was given by intragastric intubation. Tumors in the pylorus of the glandular stomach were observed in 4 out of the 29 animals receiving X-rays + AOM and in 4 out of the 25 animals receiving X-rays + PhIP, 12 months after administration. No such lesions were found in the chemical or X-ray alone groups. Intestinal metaplasia and some induced tumors were positive for CDX2. It was concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by colon carcinogens.

Gastric tumor

Azoxymethane

2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine

F344 rats

Intestinal metaplasia

Medical sciences [ 490 ]

eng

BioMed Central

Copyright (c) 2005 S. Kashiwabara et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

[ISSN] 0392-9078

[NCID] AA12034934