Elevated Brachial-Ankle Pulse Wave Velocity Is Associated with Left Ventricular Hypertrophy in Hypertensive Patients after Stroke

Masugata Hisashi

Senda Shoichi

Hoshikawa Jun

Murao Koji

Hosomi Naohisa

Okuyama Hiroyuki

Inukai Michio

Himoto Takashi

Nakatsuka Yoichi

Imai Masanobu

Noma Takahisa

Kohno Masakazu

Goda Fuminori

Tohoku Journal of Experimental Medicine

Brachial-ankle pulse wave velocity (baPWV) is widely used as a marker of arterial stiffness, but there are no data regarding the usefulness of measuring baPWV in hypertensive patients after stroke. The purpose of this study was to examine the clinical significance of baPWV by assessing its correlation with echocardiographic parameters in hypertensive patients after stroke. The study enrolled 61 hypertensives after stroke (24 patients with cerebral infarction and 37 with cerebral hemorrhage) and 61 age-matched hypertensives without stroke. Left ventricular (LV) hypertrophy was evaluated by measuring LV mass index (LVMI) and relative wall thickness (RWT), and LV diastolic function was evaluated by measuring peak early mitral annular velocities (E') using echocardiography. Concentric LV hypertrophy showing increased RWT (0.50 ± 0.12) was observed in hypertensives after stroke, but not in hypertensives without stroke. In hypertensives after stroke, elevated baPWV correlated with age (r = 0.60, p < 0.001), systolic blood pressure (r = 0.56, p < 0.001), increased LVMI (r = 0.47, p < 0.001), and decreased E' (r = -0.40, p = 0.002). Multiple regression analysis showed that age (β coefficient = 0.43, p < 0.001), systolic blood pressure (β coefficient = 0.40, p < 0.001), and LVMI (β coefficient = 0.25, p = 0.008) were independent determinants of elevated baPWV. In conclusion, elevated baPWV is more closely associated with LV hypertrophy than with LV diastolic dysfunction. Elevated baPWV is independently associated with the severity of LV hypertrophy adjusted with systolic blood pressure and age in hypertensive patients after stroke.

hypertension

Stroke

brachial-ankle pulse wave velocity

Echocardiography

left ventricular hypertrophy

Medical sciences [ 490 ]

eng

Tohoku University Medical Press

Copyright (c) 2010 東北ジャーナル刊行会

[ISSN] 0040-8727

[DOI] 10.1620/tjem.220.177

[NCID] AA00863920

[DOI] http://dx.doi.org/10.1620/tjem.220.177