Creation of highly functional CO_3Ap-collagen scaffold biomaterials
Dental Materials Journal Volume 29 Issue 1
Page 1-3
published_at 2010
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Title ( eng ) |
Creation of highly functional CO_3Ap-collagen scaffold biomaterials
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Creator | |
Source Title |
Dental Materials Journal
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Volume | 29 |
Issue | 1 |
Start Page | 1 |
End Page | 3 |
Abstract |
Physicochemical properties of apatites are affected dramatically by the substitution of trace elements. Especially, biological apatites constituting bone and teeth contain several wt% of CO32– ions, which are related to the crystallinity and solubility. Recently, scaffold biomaterials are being developed with a shape-maintaining property in addition to large pores and high porosity, into which cells can easily invade. To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO3Ap) were synthesized and CO3Ap–collagen scaffolds were created. This scaffold biomaterial is useful for regions with bone regeneration ability. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 weeks' implantation. Furthermore, when a CO3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells, as well as prominent angiogenesis inside the graft, could be detected after 1 week. Thus, the modification of higher functions such as cytokine and angiogenesis factors is effective for low regeneration regions using tissue engineering biomaterials.
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Keywords |
Scaffold biomaterials
CO_3Ap-collagen
High function
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NDC |
Medical sciences [ 490 ]
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Language |
eng
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Resource Type | journal article |
Publisher |
Japanese Society for Dental Materials and Devices
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Date of Issued | 2010 |
Rights |
Copyright (c) 2010 日本歯科理工学会
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Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0287-4547
[DOI] 10.4012/dmj.2009-R01
[NCID] AA10443149
[DOI] http://dx.doi.org/10.4012/dmj.2009-R01
[URI] http://wwwsoc.nii.ac.jp/jsdmd/2010/all2010.html#top29-1
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