Creation of highly functional CO_3Ap-collagen scaffold biomaterials

Okazaki Masayuki

Dental Materials Journal

Physicochemical properties of apatites are affected dramatically by the substitution of trace elements. Especially, biological apatites constituting bone and teeth contain several wt% of CO32– ions, which are related to the crystallinity and solubility. Recently, scaffold biomaterials are being developed with a shape-maintaining property in addition to large pores and high porosity, into which cells can easily invade. To develop a new biodegradable scaffold biomaterial, bone-like carbonate apatites (CO3Ap) were synthesized and CO3Ap–collagen scaffolds were created. This scaffold biomaterial is useful for regions with bone regeneration ability. When these sponge-frame complexes with rh-BMP2 were implanted beneath the periosteum cranii of rats, sufficient new bone was created at the surface of the periosteum cranii after 4 weeks' implantation. Furthermore, when a CO3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells, as well as prominent angiogenesis inside the graft, could be detected after 1 week. Thus, the modification of higher functions such as cytokine and angiogenesis factors is effective for low regeneration regions using tissue engineering biomaterials.

Scaffold biomaterials

CO_3Ap-collagen

High function

Medical sciences [ 490 ]

eng

Japanese Society for Dental Materials and Devices

Copyright (c) 2010 日本歯科理工学会

[ISSN] 0287-4547

[DOI] 10.4012/dmj.2009-R01

[NCID] AA10443149

[DOI] http://dx.doi.org/10.4012/dmj.2009-R01

[URI] http://wwwsoc.nii.ac.jp/jsdmd/2010/all2010.html#top29-1