Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody
Journal of Veterinary Medical Science Volume 72 Issue 3
Page 257-262
published_at 2010
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| File | |
| Title ( eng ) |
Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody
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| Creator |
Abou Elazab Mohamed Fahmy
Fukushima Yuji
Fujita Yukihiro
Matsuda Haruo
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| Source Title |
Journal of Veterinary Medical Science
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| Volume | 72 |
| Issue | 3 |
| Start Page | 257 |
| End Page | 262 |
| Abstract |
Prolonged interference or suppression of maternal antibodies of the humoral immune response of newly hatched chicks to active immunization has been documented; however, the immunological mechanisms responsible for such suppression are still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specificIgY antibodies were transferred by yolk sac inoculation to newly hatched chicks, and they were immunized with DNP-KLH or rabbit serum albumen (RSA) at 1 and 4 weeks of age. The concentrations of anti-DNP and anti-RSA antibodies in serum samples of these chicks were measured using an enzyme-linked immunosorbent assay (ELISA). The immune responses of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with an appropriate dose of DNP-KLH were suppressed. However, those of the chicks that received the same high dose of maternal non-specific IgY antibodies and were immunized with an appropriate dose of DNP-KLH and those of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with RSA were not suppressed. On the other hand, suppression of anti-DNP antibody production would not be induced if the chicks received a high dose of antigen specific maternal antibodies and were immunized with a high dose of the same antigen. These results revealed that the immune suppressive effect of maternal antibodies on the immune response of the newly hatched chicks was antigen specific and depended mainly on the ratio of antigen/maternal antibody at the time of immunization.
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| Keywords |
antigen specificity
Chick
IgY
maternal antibody
suppression
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| NDC |
Zoology [ 480 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Japanese Society of Veterinary Science
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| Date of Issued | 2010 |
| Rights |
Copyright (c) 2010 社団法人日本獣医学会
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0916-7250
[DOI] 10.1292/jvms.09-0298
[NCID] AA10796138
[DOI] http://dx.doi.org/10.1292/jvms.09-0298
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