Extrachromosomal Double Minutes and Chromosomal Homogeneously Staining Regions as Probes for Chromosome Research
Cytogenetic and Genome Research 124 巻 3-4 号
312-326 頁
2009 発行
アクセス数 : 817 件
ダウンロード数 : 333 件
今月のアクセス数 : 6 件
今月のダウンロード数 : 2 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00027768
ファイル情報(添付) |
CGR_124_312.pdf
2.26 MB
種類 :
全文
|
タイトル ( eng ) |
Extrachromosomal Double Minutes and Chromosomal Homogeneously Staining Regions as Probes for Chromosome Research
|
作成者 | |
収録物名 |
Cytogenetic and Genome Research
|
巻 | 124 |
号 | 3-4 |
開始ページ | 312 |
終了ページ | 326 |
抄録 |
Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrachromosomal double minutes (DMs) and the chromosomal homogeneously staining region (HSR). DMs are composed of autonomously replicating circular DNA of genomic origin, and they tell us about how the extrachromosomal elements may behave in the cells, how they were entrapped by the micronuclei and how they were eliminated from the cells. On the other hand, the episome model predicts that extrachromosomal elements excised from the chromosome arm might generate DMs, and the breakage-fusion-bridge (BFB) cycle model explains the generation of the HSR. In accordance with this, a plasmid bearing a mammalian replication initiation region (IR) and a matrix attachment region (MAR) mimics gene amplification and generates DMs and HSRs de novo. The IR/MAR gene amplification system extends our understanding of the mechanism of gene amplification and the behavior of amplified genes. Furthermore, the system may suggest the way how extrachromosomal elements in general may alter the chromosome architecture and function.
|
著者キーワード |
Double minutes
Gene amplification
Homogeneously staining region; Matrix attachment region
Replication initiation region
|
NDC分類 |
生物科学・一般生物学 [ 460 ]
|
言語 |
英語
|
資源タイプ | 学術雑誌論文 |
出版者 |
Karger
|
発行日 | 2009 |
出版タイプ | Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 1424-8581
[DOI] 10.1159/000218135
[NCID] AA11703143
[DOI] http://dx.doi.org/10.1159/000218135
|