筋小胞体の構造および筋活動に伴うその機能の変化

Structure of sarcoplasmic reticulum and activity-induced alteration in its function

Wada Masanobu

Inashima Shuichiro

Yasuda Toshihiro

Matsunaga Satoshi

体育學研究

Repeated contractions of skeletal muscle lead to a decline of force known as fatigue. The exact cause of muscular fatigue probably involves numerous factors which influence force production in a manner dependent on muscle fiber type and activation pattern. However, a growing amount of evidence implicates alteration of intracellular Ca2+ handling as a major contributor to fatigue. These changes are known to occur secondary to reductions in the rates of Ca2+ uptake and release by the sarcoplasmic reticulum (SR). In this brief review, we focus on two major aspects: 1) molecular mechanisms of the Ca2+ uptake and release process, focusing on Ca2+-ATPase protein and the ryanodine receptor; and 2) several factors that may be responsible for dysfunction of the SR resulting from contractile activity. Factors that might account for diminished function of the SR include a fall in internal pH, increased Ca2+ concentration, modification by reactive oxygen species, depletion of high-energy phosphate, and accumulation of inorganic phosphate.

muscular fatigue

muscle contraction

exercise

calcium

筋疲労

筋収縮

運動

カルシウム

Sports and physical training [ 780 ]

jpn

日本体育学会

Copyright (c) 2001 日本体育学会

この論文の著作権は(社)日本体育学会に帰属します

[ISSN] 0484-6710

[NCID] AN00409623