高強度運動後の回復期における筋小胞体のCa^<2+>取り込み機能の変化 : 速筋と遅筋との比較

CHANGES IN SARCOPLASMIC RETICULUM Ca^<2+>-SEQUESTERING CAPACITY DURING RECOVERY FOLLOWING HIGH-INTENSITY EXERCISE : COMPARISONS BETWEEN FAST- AND SLOW-TWITCH MUSCLES

Mishima Takaaki

Yamada Takashi

Sakamoto Makoto

Wada Masanobu

体力科学 : Japanese Journal of Physical Fitness and Sports Medicine

The purpose of this study was to investigate changes in sarcoplasmic reticulum (SR) Ca^<2+>-sequestering capacity in rat fast-twitch plantaris (PL) and slow-twitch soleus (SOL) muscles during recovery after high-intensity exercise. The rats were subjected to treadmill runs to exhaustion at the intensity (10% incline at 50m/min) estimated to require 100% of maximal O_2 consumption. The muscles were excised immediately after exercise, and 15, 30 and 60 min after exercise. Acute high-intensity exercise evoked a 27% and 38% depression (P<0.05) in SR Ca^<2+>-uptake rate in the PL and SOL, respectively. In the PL, uptake rate remained lower (P<0.05) at 30 min of recovery but recovered 60 min after exercise. These alterations were paralleled by those of SR Ca^<2+>-ATPase activity. On the other hand, SR Ca^<2+>-uptake rate in the SOL recovered 15 min after exercise. Unlike the PL, discordant time-course changes between SR Ca^<2+>-ATPase activity and uptake occurred in the SOL during recovery. SR Ca^<2+>-ATPase activities were unaltered with exercise and elevated (P<0.05) by 25, 30 and 30% at 15, 30 and 60 min of recovery, respectively. These results demonstrate that SR Ca^<2+>-sequestering ability is restored faster in slow-twitch than in fast-twitch muscle during recovery periods following a single bout of high-intensity exercise and suggest that the rapid restoration of SR Ca^<2+>-sequestering ability in slow-twitch muscle could contribute to inhibition of disturbances in contractile and structural properties that are known to occur with raised myoplasmic Ca^<2+> concentrations.

Ca^<2+> homeostasis

muscle fatigue

fiber type

Medical sciences [ 490 ]

jpn

日本体力医学会

日本体力医学会

本文データは学協会の許諾に基づきCiNiiから複製したものである

[ISSN] 0039-906X

[NCID] AN00137986

[NAID] 110004821402

[URI] http://joi.jlc.jst.go.jp/JST.JSTAGE/jspfsm/55.503