Further evidence for excitability changes in human primary motor cortex during ipsilateral voluntary contractions
Neuroscience Letters 433 巻 2 号
135-140 頁
2008-03 発行
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種類 :
全文
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タイトル ( eng ) |
Further evidence for excitability changes in human primary motor cortex during ipsilateral voluntary contractions
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作成者 |
Murakami Tsuneji
Narita Tomohiro
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収録物名 |
Neuroscience Letters
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巻 | 433 |
号 | 2 |
開始ページ | 135 |
終了ページ | 140 |
抄録 |
The present study aimed to further investigate whether the intracortical neural circuits within the primary motor cortex (M1) are modulated during ipsilateral voluntary finger movements. Single- and paired-pulse (interstimulus intervals, ISIs; 3 ms and 12 ms) transcranial magnetic stimulations of the left M1 were applied to elicit motor evoked potential (MEP) in the right first dorsal interosseous (Rt-FDI) muscle during voluntary contractions (10% and 30% maximum voluntary contraction) of the left FDI (Lt-FDI) muscle. F-waves of Rt-FDI muscle were recorded under these left index-finger conditions for ensuring that the excitability changes occur at the supraspinal level. MEPs were also recorded during motor imagery of the left index-finger abduction instead of overt movement. The results showed that, in single-pulse transcranial magnetic stimulation (TMS) paradigm, MEPs in Rt-FDI muscle were markedly enhanced during voluntary contractions of Lt-FDI muscle compared with the complete resting state. In paired-pulse TMS paradigm, the short intracortical inhibition was significantly reduced in proportion to increments of the ipsilateral muscle contraction, whereas the intracortical facilitation had no change. F-wave of Rt-FDI muscle was unchanged under these conditions, while MEP in Rt-FDI muscle was also enhanced during motor imagery of the left index-finger abduction. Based on the present results, it is suggested that the intracortical inhibitory neural circuits may be modulated in the transition from rest to activity of the ipsilateral homonymous muscle. The excitability changes in M1 might be induced by overflows of voluntary drive given to the ipsilateral limb, probably via the transcallosal pathway.
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著者キーワード |
short intracortical inhibition
SICI
intracortical facilitation
ICF
motor imagery
primary motor cortex
motor evoked potential
MEP
transcranial magnetic stimulation
TMS
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NDC分類 |
スポーツ・体育 [ 780 ]
医学 [ 490 ]
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Elsevier Ireland Ltd
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発行日 | 2008-03 |
権利情報 |
Copyright (c) 2008 Elsevier Ireland Ltd.
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出版タイプ | Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0304-3940
[DOI] 10.1016/j.neulet.2007.12.058
[NCID] AA00754925
[DOI] http://dx.doi.org/10.1016/j.neulet.2007.12.058
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