Possible therapeutic effect of lipid supplementation on neurotoxicity in liver transplant recipients

Transplant International Volume 20 Issue 7 Page 632-635 published_at 2007-07
アクセス数 : 808
ダウンロード数 : 210

今月のアクセス数 : 2
今月のダウンロード数 : 0
File
TransplInt_20-7_632.pdf 64.1 KB 種類 : fulltext
Title ( eng )
Possible therapeutic effect of lipid supplementation on neurotoxicity in liver transplant recipients
Creator
Ide Kentaro
Tahara Hiroyuki
Ishiyama Kohei
Shishida Masayuki
Irei Toshimitsu
Itamoto Toshiyuki
Source Title
Transplant International
Volume 20
Issue 7
Start Page 632
End Page 635
Abstract
Neurotoxicity represents a serious complication following liver transplantation and may be evoked by various perioperative factors or develop due to toxicity of immunosuppresion. The symptoms of neurotoxicity associated with calcineurin inhibitors (CNIs) may be reversed by discontinuing or reducing the dose of CNIs; however, this may increase the risk of rejection. To address this issue, we examined 45 adult living donor liver transplant recipients. At the time of neurotoxicity diagnosis, serum cholesterol values were significantly lower in the patients with neurotoxicity than in those without neurotoxicity. Based on our hypothesis that lipid supplementation prevents lipophilic CNIs from crossing the blood-brain barrier, soybean oil was administered to 5 patients with neurotoxicity. In all these patients, the neurological symptoms improved without discontinuing or reducing the dose of CNIs. This use of this therapy may help in avoiding insufficient immunosuppressive therapy because neither dose reduction nor substitution of CNIs would be then required.
Keywords
cholesterol
living donor liver transplantation
neurotoxicity
soybean oil
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
Blackwell Publishing
Date of Issued 2007-07
Rights
Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 0934-0874
[DOI] 10.1111/j.1432-2277.2007.00487.x
[NCID] AA10762158
[DOI] http://dx.doi.org/10.1111/j.1432-2277.2007.00487.x