Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma

Pathology International Volume 57 Issue 4 Page 190-199 published_at 2007-04
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Title ( eng )
Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma
Creator
Furonaka Osamu
Sakatani Akio
Source Title
Pathology International
Volume 57
Issue 4
Start Page 190
End Page 199
Abstract
The distinction between epithelioid mesothelioma and lung adenocarcinoma remains an important diagnostic challenge for surgical pathologists. The aim of the present study was to select a limited and appropriate panel of antibodies that can differentiate between epithelioid mesothelioma and lung adenocarcinoma. Specimens of 90 epithelioid mesotheliomas and 51 lung adenocarcinomas obtained from Japanese cases were examined using calretinin, WT1, AE1/AE3, CAM5.2, cytokeratin (CK) 5/6, vimentin, epithelial membrane antigen (EMA), thrombomodulin, CEA, CA19-9, and CA125. Ninety-six percent of epithelioid mesotheliomas were positive for calretinin; 99% for WT1; 100% for AE1/AE; 97% for CAM5.2; 70% for CK 5/6; 91% for vimentin; 96% for EMA; 71% for thrombomodulin; 77% for mesothelin; 7% for CEA; 17% for CA19-9; and 85% for CA125. In contrast, 33% of lung adenocarcinomas were positive for calretinin; 16% for WT1; 100% for AE1/AE3, CAM5.2, and EMA; 41% for CK 5/6; 47% for vimentin; 20% for thrombomodulin; 69% for mesothelin; 98% for CEA; 73% for CA19-9; and 80% for CA125. For distinguishing between epithelioid mesothelioma and lung adenocarcinoma, the combination of CEA, calretinin and each WT1 or thrombomodulin was suggested to be the best panel of immunohistochemical markers.
Keywords
adenocarcinoma
calretinin
CEA
immunohistochemistry
mesothelioma
thrombomodulin
WT1
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
Blackwell Publishing
Date of Issued 2007-04
Rights
Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 1320-5463
[DOI] 10.1111/j.1440-1827.2007.02080.x
[NCID] AA10984364
[DOI] http://dx.doi.org/10.1111/j.1440-1827.2007.02080.x